' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 1 Researches
8
USERS' SCORE
Very Good
Based on 11 Reviews
8.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Iron (as Dried Ferrous Sulfate)
45 mg
250%
Top Medical Research Studies
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9.5
Boosted mental health
I've been taking this vitamin for a couple of months and have experienced a significant enhancement in my overall health. I feel more alert and energised, which greatly benefits my creative thinking. It’s particularly useful for those with mental health conditions, including autoimmune disorders. I highly recommend it!
Read More
9.5
Noticeable improvements
I ordered iron for my mother, who has had lifelong anaemia, and domestic medications haven't helped much. After trying this affordable option, I was pleased that noticeable improvements came almost immediately. Muscle cramps disappeared by day two, and she now has no symptoms. This supplement truly works!
Read More
9.5
Raised hemoglobin levels
This iron supplement raised my hemoglobin level without causing significant discomfort, unlike others that triggered severe gastritis. I am pleased with my decision!
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 1 Researches
8
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 11 Reviews
8.9
9.5
Boosted mental health
I've been taking this vitamin for a couple of months and have experienced a significant enhancement in my overall health. I feel more alert and energised, which greatly benefits my creative thinking. It’s particularly useful for those with mental health conditions, including autoimmune disorders. I highly recommend it!
Read More
9.5
Reduced chronic pain
I ordered vitamin 31 recently, and my life has improved substantially. I've lost about 6 pounds and regained my appetite. I sleep well now, free from back pain. This vitamin has alleviated the chronic pain from my sciatica and other health issues. Thank you, Dr Clemens!
9.5
Noticeable improvements
I ordered iron for my mother, who has had lifelong anaemia, and domestic medications haven't helped much. After trying this affordable option, I was pleased that noticeable improvements came almost immediately. Muscle cramps disappeared by day two, and she now has no symptoms. This supplement truly works!
Read More
9.5
Raised hemoglobin levels
This iron supplement raised my hemoglobin level without causing significant discomfort, unlike others that triggered severe gastritis. I am pleased with my decision!
8.8
Improved iron levels
Great! Last winter, I discovered my iron levels were deficient and purchased this brand. I am very satisfied with the results; they truly helped me. I ordered more.
